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According to the Nobel Committee's statement, the three scientists, Mary E. Brunkow, Fed Ramsdell, and Shimon Sakaguchi, identified the immune system's security guards, regulatory T cells, which prevent our immune cells from attacking our own tissues. Their findings offer hope for the treatment and cure of autoimmune diseases, enable more effective cancer treatments, and may help prevent serious complications after stem cell transplants, according to the announcement.
The discoveries of these three scientists laid the foundations for a new field of science dealing with peripheral immune tolerance, giving impetus to the development of medical treatments aimed at curing cancer and autoimmune diseases. Their discovery may also increase the success rate of organ transplants, where the greatest risk is posed by the immune system attacking the new organ. Several of the treatments developed as a result of these discoveries are currently undergoing clinical trials.
Shimon Sakaguchi's work was recognized by the Faculty of Medicine at the University of Debrecen in 2023, when the Japanese professor was awarded the Debrecen Prize for Molecular Medicine.
"It is a great honor and distinction for me that the University of Debrecen has recognized my work with this award. It is an encouragement and provides motivation for my future work to continue on the path I have already started. In the future, I will continue to strive to obtain as much information as possible about regulatory T cells through my research, so that experts can achieve even more significant results in treatment based on this information, said Shimon Sakaguchi in 2023 upon receiving the Debrecen Award for Molecular Medicine.
Following the award ceremony, the distinguished professor gave a lecture entitled Regulatory T cells for controlling immunological diseases in the auditorium of the University of Debrecen, in which he presented his scientific findings.
Founded in 2003, the Debrecen Award for Molecular Medicine recognizes the work of scientists who have achieved outstanding results in the field of molecular medicine at an international level. It primarily rewards scientific activities that contribute significantly to the development of molecular medicine and whose results can be used in patient care. The value of the award is significantly enhanced by the fact that, since its inception, the Japanese professor is the third recipient, after Ralph M. Steinman and Katalin Karikó, to receive a Nobel Prize, László Mátyus, dean of the Faculty of General Medicine, told hirek.unideb.hu.
The Nobel Prize is traditionally awarded on December 10, the anniversary of the death of Alfred Nobel, who founded the award, in Stockholm.
Press Centre - CzA/ MTI
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